One Response to “How does the TEM machine differentiate between the core&shell in nanoparticles? (What generates the contrast?)”

1. By Beth H on Feb 6, 2010 | Reply

   Usually, it is diffraction that dominates TEM contrast. Diffraction, in turn, is affected by the electron density. I don’t really have much expertise in this area, though.
   I’d suggest trying the “Ask a Microscopist” tool available from the Americal Microscopy Society, here: http://www.msa.microscopy.org/Ask-A-Microscopist/Ask-A-Microscopist.html

   There is also an on-line electron microscopy course with a section on imaging mechanisms available here: http://em-outreach.ucsd.edu/web-course/toc.html